Enterprise PPC Management

queryDNA™: paid search optimization at the molecular level

Published April 15, 2025 · Updated July 10, 2026 · by the SEMoptimize founding team

Most agencies manage PPC from the keyword down. SEMoptimize builds from the search query up, because after twenty years of enterprise paid search we know something the keyword planners won't tell you: keywords are best guesses. Search queries are facts.

The opportunity

Where PPC budgets leak

Search queries hit Google every day
4.7B+
Haven't been seen by search engines in six months, if ever
15%
Have no exactly matching keyword in any search campaign
70%

That gap between what people actually type and what campaigns are built to catch is where PPC budgets leak. It's also where we work. Paid search is a pull medium: when someone hands Google their exact intent, your job is to deliver on that ask precisely, the right query, to the right keyword and match type, with the right message, bid, and landing page. Miss any link in that chain and the impression is wasted. We build campaigns in the image of your own search query data so the chain holds, impression after impression.

Where clients start

Three signs it's time to go deeper than keywords

Break a PPC plateau

Even well run campaigns plateau or decline without going deeper to reveal data driven opportunities. queryDNA finds the growth hiding beneath a mature account's keyword list.

Request a forecast

Scale enterprise budgets

From six figure monthly ad spend to multi region, national and international targeting, queryDNA's hyper segmented structure supports complex accounts without breaking under their own scale.

See enterprise results

Full funnel measurement

Connect Google Ads to your CRM and optimize to deals won and revenue earned, then forecast growth from market demand and your own pipeline, not just cost per lead.

Explore CRM integration

Definition

What is queryDNA Optimization?

queryDNA is SEMoptimize's proprietary search query architecture and algorithmic optimization process. Instead of managing a few hundred keywords, it analyzes every query your account actually receives, clusters them into hyper segmented themes, pairs each theme with purpose built ads, and bids at the query level with custom algorithms. The full process runs in five steps: account health analysis and opportunity projection, query theme analysis to eliminate damaging themes, query clustering to hyper segment the valuable long tail, ad multivariate optimization to align message to query, and a query aware bidding algorithm. It was developed over two decades of managing enterprise accounts and refined on billions of impressions. The result on mature accounts is consistently the same: more conversion volume at a more efficient cost per.

Keyword first management vs. queryDNA
DimensionTypical keyword first agencyqueryDNA (SEMoptimize)
Unit of optimizationA few hundred keywordsEvery search query the account receives
StructureSimplified account structure, generic ad groupsHyper segmented query theme clusters
MessagingOne ad stretched across a thousand intentsMultivariate tested ads per query cluster
BiddingPlatform defaults, keyword level bidsQuery level custom algorithm with match type tiers
Success metricCost per leadDeals won and revenue earned, via CRM integration

Two philosophies

Keyword down management vs. query up optimization

How queryDNA differs from conventional PPC management.

Dimension Keyword down (most agencies) Query up (SEMoptimize queryDNA)
Unit of optimizationA few hundred keywords, best guessesEvery search query the account actually receives, facts
Account structureSimplified structures that get “managed”Hyper segmented themes built in the image of your query data
MessagingOne generic ad stretched across a thousand intentsPurpose built ads per query cluster, tested combination by combination
BiddingOver bidding on inefficient head termsQuery level bidding with data driven match type tiers
MeasurementCost per leadDeals won and revenue earned, via CRM integration

Who it's for

Who is SEMoptimize the right fit for?

SEMoptimize fits established advertisers, not beginners: companies with $10M+ in annual revenue, a marketing team in place, a Google Ads account holding at least 12 months of history, and an active CRM such as Salesforce or HubSpot, especially where PPC growth has plateaued or costs keep climbing.

Annual revenue $10M+ and a marketing team in place

You are not new to paid search advertising. In fact, you have been at it for a while and know that now is the time to go to the next level. Good is the enemy of great, if you are ready to be great, you need to work with the best.

Existing Google Ads account with ≥ 12 months of data

We take all your historical data and run it through our proven process, the ideal balance of our AI tooling with human oversight and 20+ years of paid search experience. Your data and the market's data inform a search query optimization process that makes an immediate, positive impact.

Active CRM such as Salesforce or HubSpot for full funnel optimization

Imagine optimizing not only to deals won and revenue earned, but forecasting from market demand, PPC performance, and future growth goals. With SEMoptimize's full service PPC + CRM integration, that becomes a reality.

PPC growth has plateaued or costs are climbing

Even the most well intended PPC campaigns plateau or decline without going deeper to reveal data driven opportunities. With SEMoptimize you get a partner that has developed proprietary technology and methodology over 20+ years to break through plateaus and reach new heights.

The process

How we run enterprise paid search

Six steps, run as one connected system, not six line items on an invoice.

Step 1

Query Theme Analysis

We mine your full query history to find the loss leaders, the damaging themes quietly draining budget and dragging down Quality Scores, and eliminate them with extensive, theme level negatives before we spend a dollar building.

Step 2

queryDNA Theme Clustering

Positive themes get isolated into a hyper segmented structure that diversifies your keyword portfolio, ends keyword cannibalization, and amplifies the long tail most accounts leave on the table.

Step 3

Ad Multivariate Optimization

Hyper targeted messaging tested combination by combination, so every query cluster gets the ad themes that historically convert it, not one generic ad stretched across a thousand intents.

Step 4

queryDNA Bidding Algorithm

A search query based bidding algorithm with natural, data driven match type tiers that protect matching integrity and balance the whole portfolio, more revenue, better ROI, no over bidding on head terms.

Step 5

CRM Integrated Optimization

We connect Google Ads to Salesforce, HubSpot, and other systems so optimization targets deals won and revenue earned, not just cost per lead, and so we can forecast growth from market demand and your own pipeline.

Step 6

Geo Normalization & Reporting

Geographic conversion rate variance gets normalized into the bidding strategy, and our proprietary reporting serves every audience, granular detail for your managers, the KPIs that matter for your C suite.

Evidence

Does queryDNA actually work?

Yes, measurably. On one national consumer lending account, queryDNA rebuilt campaigns to produce 51% higher application volume year over year at a 22% more efficient cost per application, with brand search improving 47% and 43% on the same measures. The pattern repeats across verticals from insurance to healthcare to e-commerce.

Applications YOY
+51%
Cost / application
−22%
Brand search volume
+47%
Brand search efficiency
+43%

See the detail, including a 589% profitability lift in insurance and 701% five year e-commerce growth, in our queryDNA case studies.

Onboarding

What do the first 60 days look like?

Two tracks run in parallel: immediate day to day management captures quick wins from day one, while the full queryDNA rebuild runs alongside it, query theme analysis in the first ten days, theme categorization over three weeks, custom ad creation, the bidding algorithm, and a stabilized relaunch typically 45 to 60 days in.

Track one · Immediate

Take over and tighten

Out of the gate, we take over day to day management and capture the low hanging fruit: bidding, negatives, settings, extensions, keyword and match type gaps, and tracking cleanup, while we integrate your data sources and stand up the reporting feedback loop.

Track two · The rebuild

Run the full queryDNA process

Query theme analysis in the first ten days, positive theme categorization over the following three weeks, hyper customized ad creation with your feedback throughout, the bidding algorithm built alongside, and a constructed, stabilized relaunch typically 45 to 60 days in. You're never waiting on the rebuild to see improvement, and the rebuild is never rushed to meet an arbitrary date.

Questions

Enterprise PPC, answered

How is SEMoptimize different from other PPC agencies?

Most agencies operate on the distorted layer of keywords, match types, and simplified account structures, “managing” the account rather than rebuilding what's underneath it. We go beneath the keywords to the search queries themselves, because that's where the facts are. Campaigns built in the image of real query data need less guesswork, waste less budget, and convert more of the impressions they win.

What is queryDNA Optimization?

queryDNA is our proprietary five step process: account health analysis and opportunity projection, query theme analysis to eliminate damaging themes, query clustering to hyper segment the valuable long tail, ad multivariate optimization to align message to query, and a query aware bidding algorithm. It was developed over two decades of managing enterprise accounts and refined on billions of impressions.

Does this work with Google's Smart Bidding and AI features?

Yes, they get better together. Google's automation optimizes to whatever structure and signals you feed it; a clean, hyper segmented architecture with query level data gives it dramatically better raw material. Where Google's AI can't see, your CRM, your margins, which leads actually became customers, our integrations and custom algorithms fill the gap with human oversight on top.

What kind of company is a good fit?

Our best fit clients typically have $10M+ in annual revenue, a marketing team in place, a Google Ads account with at least 12 months of history, and an active CRM such as Salesforce or HubSpot. If PPC growth has plateaued or costs keep climbing despite competent management, that's usually the sign there's opportunity below the surface.

How do you charge, and what does reporting look like?

Engagements are scoped to your account's size and complexity, ask us for a proposal. Reporting is customized rather than templated: monthly performance summaries and meetings as the baseline, with dashboards tuned to each audience, from query level analysis for your team to executive KPI views for leadership.

Paid search is where we started, but it is half the picture: the same query intelligence now powers our SEO services and our generative engine optimization (GEO) practice, so your brand wins the ranking, the ad auction, and the AI answer.

Optimization at the molecular level

Every query is a data point. We optimize all of them.

Stop guessing

Start knowing your growth potential

We'll forecast the untapped potential in your existing account, real math from your own query data, not a sales pitch.

The Optimal Path to Conversion

With precision bidding strategy, delivering the right Keyword/Match Type, to the right Ad Message, to the right Landing Page.

Wasteful Themes Pruned - Negatives
See how queryDNA works →